2024
- Jakobsen ST, Siersbæk R. Transcriptional regulation by MYC: an emerging new model. Oncogene. 2024 Oct 28. doi: . Online ahead of print.
- Jakobsen ST, Jensen RAM, Madsen MS, Ravnsborg T, Vaagenso CS, Siersbæk MS, Einarsson H, Andersson R, Jensen ON, Siersbæk R (2024). MYC activity at enhancers drives prognostic transcriptional programs through an epigenetic switch. Nat Genet. 2024 Apr;56(4):663-674. doi: . Epub 2024 Mar 7.
2023
- Ramesh V, Gollavilli PN, Pinna L, Siddiqui MA, Turtos AM, Napoli F, Antonelli Y, Leal-Egaña A, Havelund JF, Jakobsen ST, Boiteux EL, Volante M, Faergeman NJ, Jensen ON, Siersbaek R, Somyajit K, Ceppi P (2023). Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma. EMBO Mol Med. 2023 Dec 7;15(12):e17836. doi: .
2021
- Broome R, Chernukhin I, Jamieson S, Kishore K, Papachristou EK, Mao SQ, Tejedo CG, Mahtey A, Theodorou V, Groen AJ, D'Santos C, Balasubramanian S, Farcas AM§, Siersbæk R§, Carroll JS§ (2021). TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions. Cell Rep. 2021 Feb 23;34(8):108776. doi: .
2020
- Siersbæk R§, Scabia V, Nagarajan S, Chernukhin I, Papachristou EK, Broome R, Johnston SJ, Joosten SEP, Green AR, Kumar S, Jones J, Omarjee S, Alvarez-Fernandez R, Glont S, Aitken SJ, Kishore K, Cheeseman D, Rakha EA, D'Santos C, Zwart W, Russell A, Brisken C, Carroll JS§ (2020). IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis. Cancer Cell. 14;38(3):412-423.e9. PMID: 32679107 DOI:
- Nagarajan S, Rao SV#, Sutton J#, Cheeseman D#, Dunn S, Papachristou EK, Prada JG, Couturier DL, Kumar S, Kishore K, Chilamakuri CSR, Glont SE, Archer Goode E, Brodie C, Guppy N, Natrajan R, Bruna A, Caldas C, Russell A, Siersbæk R, Yusa K, Chernukhin I, Carroll JS (2020). ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response. Nat Genet. 52(2):187-197. PMID: 31913353. DOI:
2019
- Glont SE#, Papachristou EK#, Sawle A, Holmes KA, Carroll JS§, Siersbaek R§ (2019). Identification of ChIP-seq and RIME grade antibodies for Estrogen Receptor alpha. PLoS One. 14(4):e0215340. PMID: 30970003. DOI:
2018
- Siersbæk R§, Kumar S, Carroll JS§ (2018). Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer. Genes Dev. 32(17-18):1141-1154. PMID: 30181360. DOI:
- Papachristou EK, Kishore K#, Holding AN#, Harvey K, Roumeliotis TI, Chilamakuri CSR, Omarjee S, Chia KM, Swarbrick A, Lim E, Markowetz F, Eldridge M, Siersbaek R§, D'Santos CS§, Carroll JS§ (2018). A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes. Nat Commun. 9(1):2311. PMID: 29899353. DOI:
- Michaloglou C#, Crafter C#, Siersbaek R, Delpuech O, Curwen JO, Carnevalli LS, Staniszewska AD, Polanska UM, Cheraghchi-Bashi A, Lawson M, Chernukhin I, McEwen R, Carroll JS, Cosulich SC (2018). Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor-positive Breast Cancer. Mol Cancer Ther. 17(5):908-920. PMID: 29483206. DOI:
2017
- Sarusi Portuguez A, Schwartz M, Siersbaek R, Nielsen R, Sung MH, Mandrup S, Kaplan T, Hakim O (2017). Hierarchical role for transcription factors and chromatin structure in genome organization along adipogenesis. FEBS J. 284(19):3230-3244. PMID: 28755519. DOI:
- Siersbæk R#, Madsen JGS#, Javierre BM#, Nielsen R#, Bagge EK, Cairns J, Wingett SW, Traynor S, Spivakov M, Fraser P§, Mandrup S§ (2017). Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation. Mol Cell. 66(3):420-435.e5. PMID: 28475875. DOI:
2014
- Rakhshandehroo M, Gijzel SM#, Siersbæk R#, Broekema MF#, de Haar C, Schipper HS, Boes M, Mandrup S, Kalkhoven E (2014). CD1d-mediated presentation of endogenous lipid antigens by adipocytes requires microsomal triglyceride transfer protein. J Biol Chem. 289(32):22128-39. PMID: 24966328. DOI:
- Siersbæk R, Baek S, Rabiee A, Nielsen R, Traynor S, Clark N, Sandelin A, Jensen ON, Sung MH, Hager GL, Mandrup S (2014). Molecular architecture of transcription factor hotspots in early adipogenesis. Cell Rep. 7(5):1434-1442. PMID: 24857666. DOI:
- Siersbæk R#, Rabiee A#, Nielsen R, Sidoli S, Traynor S, Loft A, Poulsen LC, Rogowska-Wrzesinska A, Jensen ON, Mandrup S (2014). Transcription factor cooperativity in early adipogenic hotspots and super-enhancers. Cell Rep. 7(5):1443-1455. PMID: 24857652. DOI:
- Madsen MS, Siersbæk R, Boergesen M, Nielsen R, Mandrup S (2014). Peroxisome proliferator-activated receptor γ and C/EBPα synergistically activate key metabolic adipocyte genes by assisted loading. Mol Cell Biol. 34(6):939-54. PMID: 24379442. DOI:
2012
- Siersbæk R, Nielsen R, Mandrup S (2012). Transcriptional networks and chromatin remodeling controlling adipogenesis. Trends Endocrinol Metab. 23(2):56-64. PMID: 22079269. DOI:
2011
- Siersbæk R, Nielsen R, John S, Sung MH, Baek S, Loft A, Hager GL§, Mandrup S§ (2011). Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis. EMBO J. 30(8):1459-72. PMID: 21427703. DOI:
- Aagaard MM#, Siersbæk R#, Mandrup S (2011). Molecular basis for gene-specific transactivation by nuclear receptors. Biochim Biophys Acta. 1812(8):824-35. PMID: 21193032. DOI:
2010
- Siersbaek R, Nielsen R, Mandrup S (2010). PPARgamma in adipocyte differentiation and metabolism--novel insights from genome-wide studies. FEBS Lett. 584(15):3242-9. PMID: 20542036. DOI:
2008
- Nielsen R#, Pedersen TA#, Hagenbeek D#, Moulos P, Siersbaek R, Megens E, Denissov S, Børgesen M, Francoijs KJ, Mandrup S§, Stunnenberg HG§ (2008). Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis. Genes Dev. 22(21):2953-67. PMID: 18981474. DOI:
# Equal contribution, § Co-correspondence.