One of the most fundamental challenges for all living organisms is to sense and respond to nutrient-derived signals in order to adapt their metabolism and physiology to promote survival and achieve balanced growth. Thus, import, transport, synthesis, and metabolism of a large variety of metabolites and macromolecules must be strictly coordinated to meet the nutritional requirements of cells and organisms.
Coordination of these cellular activities most often occurs on a very short time scale, concurrent with nutritional changes in the environment. Eukaryotic cells have developed numerous signaling pathways for sensing and responding to the availability of carbon sources, nitrogen sources, amino acids, or other nutrients.
We are interested in understanding the molecular mechanisms and networks that control, establish and maintain cellular energy and lipid metabolism to support growth and survival of cells and organisms in response to nutritional and genetic changes. By means of genetic-, omic-, and biochemical tools, we identify signaling mechanisms that mediate starvation responses and regulate energy- and lipid metabolism.
Relevant publications
Fredens, J., Engholm-Keller, K., Giessing, A., Pultz, D., Larsen, M. R., Højrup, P, Møller-Jensen, J. and Færgeman, N. J. (2011)
Nature Methods 8, 845-847
Pultz, D., Bennetzen, M., Rødkær, S. V., Zimmermann, C., Enserink, J. M., Andersen, J. S. and Færgeman, N. J. (2012)
Molecular Biosystems 8, 796-803
Rødkær, S. V., Pultz, D., Brusch, M., Bennetzen, M. V., Falkenby, L. G., Andersen, J. S., and Færgeman, N. J. (2014)
Mol. Biosystems 10, 2176-2188
Harvald, E. B., Sprenger, R. R., Dall, K. B., Ejsing, C. S., Nielsen, R., Mandrup, S., Murillo, A. B., Larance, M., Gartner, A., Lamond, A. I. and Færgeman, N. J. (2017)
Cell Systems 5(1), 38-52
Dall KB and Færgeman NJ, Genes and Nutrition 2019 Aug, 14, 25
Dall et al., Aging cell 2021, Mar 16